FAR EASTERN FEDERAL UNIVERSITY SCHOOL OF BIOMEDICINE GENE THERAPHY BY KRISHNAMURTHY BANUMATHY GROUP -4

FAR EASTERN FEDERAL UNIVERSITY
SCHOOL OF BIOMEDICINE
GENE THERAPHY
BY
KRISHNAMURTHY BANUMATHY
GROUP -4(E)

INTRODUCTION
GENE THERAPHY IS USED FOR PEVENT GENETIC DISORDER OR CHRONIC DISEASE WITH THE USE OF GENES AND TECHNIQUES OF GENETIC ENGINEERING AND ALSO WE HAVE MANY TECHNIQUES AND THEY STILL IN EXPERIMENTAL STAGES.IN FUTURE THIS TECHNIQUES MAY ALLOW DOCTER TO TREAT DISORDER BY INSERTING GENE INTO PATIENTS CELL INSTEAD OF USING DRUG OR SURGERY .THE GENE THERAPHY DEVELOPMENT LIES ON THE TRANSFER GENETIC MTERIAL MATERIAL INTO NUCLEI OF INDIVIDUAL CELLS ,THEN ONLY WE WILL REPRODUCED IN NORMAL COURSE OF CELL DIVISION AND WE WILL HAVE A LASTING EFFECTS .THE REASEARCHERS ARE ALSO TESTING SEVERAL APPROCHES IN GENE THERAPHY.THEY ARE USED TO INTRODUCE NEW GENE IN OUR BODY AGAINST DISEASE.AND REPLACE MUTATED GENE WITH HEALTHY COPY OF GENE .

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DEVELOPMENTS AND RESEARCH IN GENE THERAPHY
THE MOST GENE THERAPHY TRIALS ARE DOING IN US(UNITED STATES),AND EUROPE AND ALSO SOME COUNTRIES NOW INTIATING THAT’S INCLUDES AUSTRALIA .A FORM OF IMMUNE DEFENCIES ADENOSINE DEAMINASE DEFICIENCY IS THE FIRST TREATED IN HUMAN IN 1990 BY USING GENE THERAPHY AND NOW ALSO GENE THERAPHY IS USED FOR TREATING MANY NEW MELANOMA AND SOME HERIDARY DISEASE WHICH CAUSE IMPAIRED VISION .

DESPITE OF OUR HOPE IT CAN ALSO USED TO CURE CANCER AIDS AND IT CAN ALSO REVERSE THEIR FUNCTION BY MAKING ABNORMAL GENE TO THEIR NORMAL ACTIVITY.HOWEVER IN CONTRAST TO SUCCESFUL GENE THERAPHY FOR MEDICAL PURPOSE REQIURES THE MEETING AND MAINTAINCES OF RIQUIOR .IT INCLUDE THAT TRANSFERRED GENE TO CELL WHERE IT GET MAXIMUM POTENTIAL IT ALSO VARIES FOR DIFFERENT DISEASE. THE NEW GENE CURING IS LONG LASTING AND PRODUCE ENOUGH FACTOR TO ENSURE BLOOD CLOTING . THE HEALTHY GENES ARE NOT DISTRUBED BY NEW TRANSGENES . BENEFITS OF GENE THERAPHY
YES WE NEED TO USE GERMLINE GENE THERAPHY BECAUSE IT ENABLE US TO CORRECTION DISEASE CAUSING MUTATION THAT PASS FROM ONE GENERATION TO OTHER SPARING FUTURE GENERATION FROM SUFFERING FROM DISEASE AND IT ALSO MADE OUR GENERATION TO BE HEALTHY .WITH WIDESPREAD OF GERM LINE GENE THERAPHY PARTICULAR GENETIC CONDITION COULD BE ELIMINATED FROM THE POPULATION ALTOGETHER . HUNTINGTONS DISEASE COULD BECOME DISEASE OF PAST LIKEWISE BY THE MEANS OF GENE THERAPHY WE CAN MAKE MORE DISEASE ERACIATED FROM OUR GLOBAL .
THIS REGULATION PREVENTS GENE THERAPHY BEEN USED TO SELECT CHARACTER FOR NON-MEDICAL PURPOSE TO DESINE BABY. IT ENSURE THAT GENETIC MODIFICATION PRACTICES AND IT CREATE POTENTIAL HARMFUL THINGS ARE AVOID TOGETHER . IN THE UNITED KINGDOM THE GENE THERAPHY ADSVISE COMMITE WAS INTRODUCE IN 19937TO REGULATE THE BENEFITS OF GERMLINE GENE THERAPHY IT ENABLES THE GENERATION BEING TREATED TO LEAD A HEALTHY LIFE. THE US NATIONAL HUMAN GENOME RESEARCH INSTITUTE, AIMS TO IDENTIFY ALL ETHICAL AND LEGAL ISSUES LINK WITH SOME GENETIC RESEARCH. IT BELIEVES THAT CONSIDER OF THE ETHICAL ARGUMENTS SHOULD IN ASSOCIATED WITH NEWMEDICAL MODIFICATION PRACTICES, INSTEAD OF DOING NOTHING .

IT WILL HELP TO CREATE THAT POTENTIALLY SOME HARMFUL PROBLEMS ARE ALSO AVOIDED ALTOGETHER. IF GERMLINE GENE THERAPY HAS THE POWER TO ELIMINATE A DISEASE TOTALLY FROM THE POPULATION IT WILL DECREASE REMOVE THE LONG TERM HEALTHCARE COSTS OF TREATING THE DISEASE. THIS IS LIKELY TO JUSTIFY IT BEING AVAILABLE THROUGH THE NATIONAL HEALTH SERVICE (NHS) IN THE UK. MAY THE GERMLINE GENE THERAPY HAS THE POTENTIAL TO DESTRY OR ELIMINATE A DISEASE COMPLETELY FROM THE POPULATION IT WILL REDUCE/REMOVE THE LONG TERM HEALTH COSTS OF TREATING THE DISEASE. IT ALSO JUSTIFY BY UK

DEFECTS AND WHY WE ARE NOT ACCEPTING GENE THERAPY
THE DEFECTSOF GENE THERAPY ARE TOO NOT JUGEDABLE. ALTHOUGH WHETHER THE THERAPY SUCCESSFULLY CURES THE DISORDER, OTHER CHANGE CAN POTENTIALLY BE INTRODUCED.BUT THE GERMLINE GENE THERAPY TARGETS THE SPERM CELLS OR OVARY , ANY ADDITIONAL CHANGE THAT ARE INTRODUCED AS A RESULT WILL BE PASSED ON TO THE FUTURE GENERATION. PEOPLE PRODUCED THROUGH GERMLINE GENE THERAPY IT WILL NOT GIVE THEIR IDEA FOR THEIR GENETIC MATERIAL TO BE MODIFIED. IN SOME CASES GERMLINE GENE THERAPY COULD BE USED TO SELECT FOR PARTICULAR PHYSICAL CHARACTER REGARDLESS OF WHETHER THEY ARE IMPORTANT FOR THE HEALTH OF THE PEOPLE . ON A LARGE SCALE, GERMLINE GENE THERAPY COULD RESULT IN THE SELECT THE CHARACTER TO “ENHANCE” THE GENETICS OF A POPULATION.

THE MAJOR USE OF THIS GERMLINE GENE THERAPY MAY MAKE SOCIETY LESS CHANCE FOR ACCEPT OF PEOPLE WHO ARE VARITY OR WHO HAVE A SOME INDIVUDUAL DISABILITY OR GENETIC CONDITION.
GERMLINE GENE THERAPY INVOLVES MORE STEPS AND INTRODUCES ADDITIONAL RISKS TO THE EMBRYO COMPARED WITH IVF (INVITRO FERTILIZATION)AND VIEW FOR HEALTHY EMBRYOS BEFORE IMPLANTATION. DISCUSSION AGAINST
THERE ARE SOME DISSCUSION AGAINST SOMATIC CELL GENE THERAPY. SOME TELL THAT YOU MIGHT CHANGE THE GERM LINE.
OTHERS SAY IT IS NEW AND EXPERIMENTAL, AND HAS UNKNOWN RISKS. BE THAT AS IT MAY, FOR SOMATIC CELL GENE THERAPY THE ADVANTAGES OR MERITS IT COULD BE GENERALLY HELD TO DESTROY OR ELIMINATE THE RISKS OF DANGER. THE MAJORITY OF THE DISCUUSION HERE ARE AGAINST GERM-LINE GENE THERAPY IT HAS MORE SIDE EFFECTS THAN THE SOMATIC GENE THERAPHY OTHERS FUTURE GENERATION WILL SUFFER
SOME MISTAKE YOU MAKE ON A GERM LINE IS PASSED TO FUTURE GENERATIONS, AND MAY AFFECT THOUSANDS OF PEOPLE
THE AFFECTED PEOPLE CAN USE THE GERMLINE GENE THERAPHY FOR NOW BUT IT NOT THE GOOD WAY FOR FUTURE GENERATION.

YOU HAVE NO RIGHT TO PLAY WITH NATURE OR GOD
AT THIS POINT WHEN GENE THERAPY WRONG, IT COULD LEAD TO TERRIFIC MUTATIONS
TREATING ABNORMAL GENES PUTS YOU ON A MOST DANGEROUS CONDITION – SOON YOU WILL BE ‘CURING’ BALDNESS, OBESITY, POOR EYEPROBLEM ETC – ACTUALLY ENHANCING THE POPULATION, LIKE THE IDEAS OF GENIUS HITLER OF A MASTER RACEONLY RICH PEOPLE WILL BE ABLE TO AFFORD THESE TREATMENTS – IT GOES AGAINST IDEAS OF EQUALITY AND JUSTICE WE HAVE CONSIDER OUR FUTURE GENERATION AND THEN WE HAVE TO DO SUCH THERAPHY
CONCLUSION
THE QUESTION WAS IF GENE THERAPY COULD CURE GENETIC DISEASES. AFTER OBTAINING NEWS ABOUT THE GENE THERAPHY AND VIEWS FROM VARITY OF PROPESPECTS , I CAN CONCLUDE THAT GENE THERAPY HAS THE POTENTIAL TO CURE DISEASES SUCH AS GENETIC DISEASEAND PARKINSON’S DISEASE, HOWEVER, IT CANNOT BE PROVEN NOW TO BE AN EFFECTIVEANG GOOD TREATMENT FOR OUR PEOPLES. ALTHOUGH THEIR IS NO POSSIBLETHAT THE VECTOR CARRY THE HEALTHY GENE WILL LAND IN THE PLACE IT IS INTENDED, IN LATER TESTS MAY MAKE IT A POSSIBLE GUARANTEE. OF THE TESTS THAT WERE DONE USING GENE THERAPY, THE PATIENT WAS ONLY HELPED FOR A LIITTLE TIME PERIOD OF TIME
REFERENCE
HTTP://GHR.NLM.NIH.GOV/PRIMER/THERAPHY/ETHICS HTTPS://WWW.YOURGENOME.ORG/DEBATES/ISGERMLINE-GENE THERAPHY ETHICALS

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