Different more than 5mg/kg for human 14. However

Different regions in the world have set different tolerable levels of aluminum in public water supply and in dietary food and none of these set barrier were more than 5mg/kg for human 14. However multiple exposure may lead to exposure to enhanced amount of aluminium as A number of previous studies has reported the aluminum toxicity based on various biochemical analysis 10. Serum aluminum level greater than 50-60 µg/L indicates overload of aluminum, which may correlate with toxicity. Aluminum exerts toxic effects via various mechanisms but the main mechanisms of this toxicity has been reported to be the inhibition of the enzyme activity and alteration in nucleic acid function through protein synthesis leading to changes in cell membrane permeability15. As aluminum toxicity has recently become a matter of concern, several researches have been initiated to discover natural dietary sources that can reduce this harmful effect of aluminum on health 9,16–18. This study found the growth of the adult female Wistar rats less in the aluminum treated group than the control group. The similar kinds of results were also observed in other studies 19. The underlying mechanism owing to the restarted weight gain could be the enhanced mobilization of the fatty deposits due to the increased glucose synthesis from the non-carbohydrate sources 20. Also, Aluminum intake was found to be causing anorexia linked with decreased thyroid activity in another study which may have reduced the food intake in the aluminum treated group which contributed to the alleviated weight gain 21. Anorexia owing to decrease weight loss was also been reported in pregnant rat model where aluminum was administered 22. An interesting observation of this study is that, initially the average body weight of the rats from aluminum plus vitamin E


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