Analysis of blood smears are usually done in patients with anemia. Laboratory-initiated examinations of blood smears for patients with anemia are typically needed whenever the hemoglobin concentration is unpredictably low.
This is bucked up since the consideration of the blood smear and red-cell indices is a logical step in the examination of any unexplained anemia. Modern automated instruments impart worthy information about the nature of anemia. They check not only a red-cell count, mean cell volume, mean cell hemoglobin (measure of the average amount of hemoglobin in an individual red cell), and the mean cell hemoglobin concentration (measure of the average concentration of hemoglobin in a cell) then also new variables that give information that beforehand could be derived only from a blood smear. These variables usually contain the red-cell-distribution width, which correlates on a blood smear with anisocytosis, and they may also comprise the hemoglobin-distribution width and percentages of hypochromic and hyperchromic cells, which associate with anisochromasia, hypochromia, and hyperchromasia. A variety of histograms and scatterplots give a visual representation of red-cell characteristics.
It may be achievable to detect an increased number of hyperchromic cells