ABSTRACT Yasmein Zein El Abdeen Abd El Ghaffar

ABSTRACT

Yasmein Zein El Abdeen Abd El Ghaffar, Effect of Some Environmemtal Factors On Immunity Measurements and Their Gene Expression in Rabbits. Unpublished Ph.D. Thesis, Department of Poultry Production, Faculty of Agriculture, Ain Shams University, 2018.

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This study aimed to study the effect of season and age and their interaction on (1) productive traits (2) Oxidative profile parameters (3) Metabolic rate (4) innate immunity traits (5) Leptin hormone level (6) innate and specific immunity traits and Leptin hormone level as response to “Pasteurella” vaccine. This work was carried out in Sakha Breeding Station (Kafr Elsheikh Governorate), Animal Production Research Institute, Agricultural Research Center, Ministry of Agriculture, Egypt. This work continued for one complete year and the experiment included the four seasons; Autumn, Winter, Spring and Summer. Also , Leptin hormone level and innate and specific immunity traits studied as response to “Pasteurella” vaccine. Total of 20 rabbits at 8 week of age in each season divided to 2 groups; in first group rabbits injected by vaccine (Pasteurella) then re-injection with vaccine after 15 days, in second group rabbits injected by saline then re-injection with vaccine after 15 days. In each seasons 15 rabbits were sacrificed from vaccinated or unvaccinated at 8, 10 and 12 weeks to take the spleen for assaying the gene expression. The analyses of weekly individual bunny weights in winter are higher than other season. Average daily gain and daily feed intake from the 5th to 12th week were 23.7 and 85.9 , respectively. The period of the year (heat stress) affected adversely on the studied traits and the effects were significant on daily gain and daily feed intake from the 5 to 12 weeks. Hydrogen Peroxide was significantly (p

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